OmpF

OmpF is a major outer membrane porin found in E. coli. Mutations in the ompF gene result in a reduced sensitivity of the E. coli cell to proteins such as Colicins, and also bacteriophages.

OmpF production is regulated by OmpR, a protein that is phosphorylated by EnvZ to induce DNA binding to the promotor region of OmpF, and repress transcription of OmpF.

This structure shows a monomer of OmpF, bound to a synthetic construct of a region of the translocation domain of Colicin E9.